TLR7-iODN (inhibitory ODN) Endotoxin-free (sterile) Cat. No. #IAX-200-056

Name: TLR7-iODN (inhibitory ODN) Endotoxin-free (sterile) Cat. No. #IAX-200-056 - 100 ug, UK VAT
Brand: Innaxon
Price: 117.60 GBP
Availability: InStock

TLR7 selective antagonist.

[1] A TLR7 antagonist restricts interferon-dependent and -independent immunopathology in a mouse model of severe influenza. Rappe JCF, et al. J. Exp. Med. (2021); 218:e20201631

£289.52

Description Features Resources

Sequence	5’-tgcttgcaagcttgcaagca-3’ (lower case letters: phosphorothioate linkage: nuclease resistant)
Synonyms	TLR7 inhibitory ODNs (iODNs)
MW	6,761 g/mol
Formulation	Lyophilised. Sterile. 100µg size includes 1.5ml ddWater Endotoxin-free (sterile) (Cat. No.: IAX-900-002-LD15). 1mg size includes 10ml ddWater Endotoxin-free (sterile) (Cat. No.: IAX-900-002-L010).
Endotoxin-free	Bacterial Endotoxin Test (kinetic turbidimetric LAL method) according to Ph. Eur. 9. Passed according to specification: Endotoxin-free: <0.002 EU/µg.
Sterility	Filter method: according to Ph. Eur. 9. Passed according to specification: • No growth in Thioglycolate medium at 30-35°C after 14 days. • No growth in Soybean Casein Digest Broth (TSB) at 20-25°C after 14 days.

Handling	Keep sterile. Reconstitution: Dissolve total vial content in sterile endotoxin-free water or PBS. Add 50% of solvent and let dissolve for 10min. Add remaining 50% of the solvent and mix thoroughly. Moderate warming may aid dissolving.
Activity	iODN for in vivo use in rodents (50-150µg per injection). For inactive control without agonistic nor antagonistic activity: CTRL2-ODN (Cat. No.: IAX-200-208).

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