SMA Universal with pH-Selector Cat. No. #IAX-700-205

Name: SMA Universal with pH-Selector Cat. No. #IAX-700-205 - 500 mg, VAT Exempt
Brand: Innaxon
Price: 225.00 GBP
Availability: InStock

• A nanoparticle (11-40nm) drug delivery system comprising a discoidal phospholipid bilayer • membrane stabilised by a chaperone molecular annulus.

• All components are batch tested for Lipodisq™ formation using validated buffer systems, which are assessed by Dynamic Light Scattering (DLS) to confirm nano-formulated drug characteristics. The buffer solutions themselves are endotoxin tested and supplied sterile.

• Lipodisq™ formation is highly efficient and shows a good safety profile, suitable for in vitro and in vivo (in experimental animals) investigations.

Enables membrane proteins (MP) to be reconstituted within phospholipid membrane mimics
without the use of mediating detergent. Nanodiscs formed from SMA are also referred to as styrene
maleic acid lipid particles (SMALP). SMA-lipid particles are formed by directly extracting membrane
proteins either from native cellular membranes (giving native nanodiscs) or from an intermediary
MP-reconstituted synthetic membrane system to ultimately form self-assembled discoidal nano-structures
of a general diameter of 10–12 nm.
• uSMA requires only a single polymer grade to be used, avoids the need to select several SMA
grades that each operate only over a narrow pH range
• uSMA can be tailored to operate over a wide pH range 4.5-8.5 by simple addition of standard
quantities of pH-Selector™
• uSMA is insensitive to presence of divalent cations, Ca2+(<10mM) and Mg2+ (<30mM),
suitable for use with ion pores, ABC transporters and ion sensitive GPCR assemblies
• uSMA can be modified to form larger particles, reducing direct interactions between the polymer
chaperone and membrane‑bound proteins
The ability of SMA to create monodisperse nanodiscs covering a range of particle sizes facilitates
the reconstitution of oligomeric MPs and MP complexes for analysis by various methods including
fluorescence microscopy, NMR and single-particle cryo-EM. Lipodisq™ technology is a proprietary
technology developed by Malvern Cosmeceutics Limited and is subject to granted international patents.
See: https://lipodisq.com.

£95.00

Description Features Resources

Synonyms	Lipodisq™ Styrene:Maleic Anhydride Copolymer Universal (pre-hydrolyzed) with pH-Selector^TM, [uSMA with pH-Selector^TM], P(SMA) with pH Selector^TM
Molecular Formula	C₁₂H₁₀O₄Na₂
Size	100mg size includes 0.5ml pH-Selector^TM and 500mg size includes 2.5ml pH-Selector^TM
MW	Polymer MW average: M_W: 5,500 M_W: MW based on weight / M_N: 2,100 M_N: MW based on number
CAS	26762-29-8
Purity	>98%
Solution pH	4.5 to 8.5 in 5% ddWater depending upon the addition of pH-SelectorTM
Solubility	Soluble in water, and buffer solutions (pH 4.50-8.50) to allow the formulation of a proprietary, thermostable, aqueous lipid nanoparticle (Lipodisq^TM, Malvern Cosmeceutics Ltd., Malvern UK). uSMA with pH-Selector^TM has overcome the limitations using divalent ions or narrow, defined pH ranges usually an inherent property of P(SMA), which can cause P(SMA) precipitation or interfere with SMA-Lipid Particle formulation or stability. Compatible with Ca⁺⁺ (10mM) or Mg⁺⁺ (30mM).
Formulation with Phospholipids	Lipodisq^TM are nanosized lipid-based discoidal particles that can be produced with P(SMA)and lipids such as DMPC (1,2-Dimyristoyl-sn-glycero-3-phosphocholine) (14:0 PC) (DMPC: IAX-700-400) to incorporate hydrophobic, poorly water-soluble active compounds, such as peptides, lipids, lipoproteins, transmembrane proteins and glycolipids. Applications of Lipodisq^TM include functional and structural characterisation of the embedded cargo, drug delivery with enhanced bioavailability, or extended biological half-life in vivo (PD/PK) and delivery of antigens maintained in their native conformation for immunization purposes.
Appearance	White powder
Handling	Keep dry. Avoid skin and eye contact.
Shipping	Ambient
Storage	2-8°C or 15-25°C
Stability	Upon receipt, store product at ambient temperature. Freezing is not recommended. In its unopened original vial, the product is stable for at least 36 months when stored at ambient temperature. Once the glass vial is opened, or solubilized in sterile, endotoxin-free ddWater (IAX-900-902) or in pH-SelectorTM or buffers and aliquoted into sterile vials under sterile conditions, the SMA polymer solution (e.g. at 5%) remains stable for at least 1 month when stored at 2-8°C and kept sterile.

Lipodisq^TM Technology

A nanoparticle (11-40nm) drug delivery system comprising a discoidal phospholipid bilayer membrane stabilised by a chaperone molecule annulus.
Internal properties of the phospholipid membrane support the disposition and stabilisation of drug molecule candidates and preserve the native conformation of membrane molecules.
The resulting encapsulated actives are rendered water-soluble and specialised for intra-cellular penetration/delivery via endosomal uptake mechanisms.
Lipodisq^TM solutions show a good safety profile and are suitable for in vitro and in vivo investigations.
For a customizable biodegradable Lipodisq^TM version with a higher concentration of actives or an alternative lipid option, contact Innaxon.

Innaxon as the supplier also welcomes BULK enquiries for this product.

Legal Claim
The Lipodisq^TM technology is covered by one or more of the following patents owned by Malvern Cosmeceutics Limited: AU2006253886, CA2611144, CN101184473B, EP1890675, GB2426703, IN261468, JP5142898, US8623414 and WO/2021/005340A1 pending.

The purchaser is licensed under those patents to use these assemblies for the purpose of research and development only but not for the purpose of delivery of agents for clinical use to humans or veterinary use to animals for therapeutic, diagnostic or prophylactic purposes, which uses are specifically prohibited.

Authorized Uses & Restrictions
The purchase of Innaxon product(s) conveys to the buyer the non-transferable right to use the purchased amount of the product and all replicates and derivatives for, internal, non-profit research purposes. The buyer cannot sell, resale or otherwise transfer (a) the product (b) its components or (c) materials made using this product or its components to a third party. The buyer agrees that any activity undertaken with the product and replicates or derivatives will be conducted in compliance with all applicable guidelines, aws, and regulations. The buyer agrees that the product and replicates or derivatives will not be used for any animal or human therapeutic or diagnostic use.

Limited Use License
Purchase does not include any other right or license to use, develop or otherwise exploit our products. Any use of Innaxon products outside of the Authorized Uses requires additional rights from the Licensor.

Download Product Resources

Product Data Sheet Universal SMA with pH-Selector^TM

Lipodisq™ Styrene: Maleic Acid Copolymer [SMA] - Flyer