Retinoic Acid powered by LipodisqTM Sterile Solution Cat. No. #IAX-700-109

Name: Retinoic Acid powered by LipodisqTM Sterile Solution Cat. No. #IAX-700-109 - 1 ml, UK VAT
Brand: Innaxon
SKU: IAX-700-109-L001
Price: 165.00 GBP
Availability: InStock

• Vitamin A is a fat-soluble micronutrient necessary for the growth of healthy skin and hair. However, both too little and too much vitamin A has deleterious effects. All-transretinoic acid (ATRA) and retinal are the main active metabolites of vitamin A. Retinoic acid dose-dependently regulates hair follicle stem cells, influencing the functioning of the hair cycle, wound healing, and melanocyte stem cells. Retinoic acid also influences melanocyte differentiation and proliferation in a dose-dependent and temporal manner. Levels of retinoids decline when exposed to ultraviolet irradiation in the skin.

• All-trans-retinoic acid (ATRA) is effective for preventing cancer and treating skin diseases and acute promyelocytic leukaemia (APL). These pharmacological effects of ATRA are mainly mediated by retinoid X receptors (RXRs) and retinoic acid receptors (RARs). These included two families of receptors, the RAR isotypes (a,b, and g) along with three RXR isotypes (a,b, and g), which bind as RXR/RAR heterodimers to cis-acting response elements of RA target genes to generate a high degree of complexity. • Retinoic acid is used in the treatment of psoriasis, ichthyosis, follicular keratosis, acne, lichen planus, verrucous epidermal nevus, impetigo, vitiligo, lichen psoriasis, the face of pityriasis alba.

£165.00

Description Features Resources

Synonyms	all-trans-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid, Tretinoin, all-trans-Retinoic acid (ATRA), Vitamin A acid in a detergent-free nano-formulation made of styrene-maleic acid lipid particles (SMA-Lipid Particles)
Empirical Formula	C₂₀H₂₈O₂
Concentration	1mg/ml (0.1% w/vol)
Size	1ml
MW	300.44
CAS	302-79-4
Purity	≥ 95% (HPLC)
Solution pH	7.00-7.50
Solubility	Soluble in water, PBS, Tris and other physiological solutions as formulated in a proprietary, thermostable, aqueous lipid nanoparticulate formulation (Lipodisq^TM, Malvern Cosmeceutics Ltd., Malvern UK). Avoid the use of buffers with divalent ions such as Ca⁺⁺ or Mg⁺⁺ or pH <6.5 or >8.0, which can cause particle instability. Unformulated Retinoic Acid is soluble in Chloroform, DMSO or ethanol. Insoluble in water.
Formulation	Lipodisq^TM are nanosized lipid-based discoidal particles that can be manufactured to incorporate hydrophobic, poorly water-soluble compounds, such as lipids, lipoproteins and glycolipids.

Appearance	Light yellow clear aqueous solution
Handling	Protect from light! Keep sterile. Avoid skin and eye contact.
Activity	Cell culture tested (human macrophage cell line) (MTT). Recommended starting dilution: 1:200 or higher. Optimal working concentrations depend on the applications and need to be determined. Published procedures using Lipodisq^TM formulations (Curcumin and IAXO TLR4 antagonists) in vivo rodent models at 3-10mg/kg. Recommended route of administration is subcutaneous (s.c.) with oral or nasal application as a possible alternative, which needs to be optimised. Carrier only control: Lipodisq^TMControl Sterile Solution (Cat. No.: IAX-700-100).

Shipping	Ambient
Storage	2-8°C
Stability	In its unopened original vial, the product is stable for at least 12 months. Once the glass vial is opened, or if aliquoted into sterile vials under sterile conditions, the product remains stable for an additional 2 months at 2-8°C. Pre-diluted, sterile aqueous solutions are stable for at least 24 hours when stored at 2-8°C.

Lipodisq^TM Technology

A nanoparticle (11-40nm) drug delivery system comprising a discoidal phospholipid bilayer membrane stabilised by a chaperone molecule annulus.
Internal properties of the phospholipid membrane support the disposition and stabilisation of drug molecule candidates and preserve the native conformation of membrane molecules.
The resulting encapsulated actives are rendered water-soluble and specialised for intra-cellular penetration/delivery via endosomal uptake mechanisms.
Lipodisq^TM solutions show a good safety profile and are suitable for in vitro and in vivo investigations.
For a customizable biodegradable Lipodisq^TM version with a higher concentration of actives or an alternative lipid option, contact Innaxon.

Innaxon as the supplier also welcomes BULK enquiries for this product.

Legal Claim
The Lipodisq^TM technology is covered by one or more of the following patents owned by Malvern Cosmeceutics Limited: AU2006253886, CA2611144, CN101184473B, EP1890675, GB2426703, IN261468, JP5142898, US8623414 and WO/2021/005340A1 pending.

The purchaser is licensed under those patents to use these assemblies for the purpose of research and development only but not for the purpose of delivery of agents for clinical use to humans or veterinary use to animals for therapeutic, diagnostic or prophylactic purposes, which uses are specifically prohibited.

Authorized Uses & Restrictions
The purchase of Innaxon product(s) conveys to the buyer the non-transferable right to use the purchased amount of the product and all replicates and derivatives for, internal, non-profit research purposes. The buyer cannot sell, resale or otherwise transfer (a) the product (b) its components or (c) materials made using this product or its components to a third party. The buyer agrees that any activity undertaken with the product and replicates or derivatives will be conducted in compliance with all applicable guidelines, aws, and regulations. The buyer agrees that the product and replicates or derivatives will not be used for any animal or human therapeutic or diagnostic use.

Limited Use License
Purchase does not include any other right or license to use, develop or otherwise exploit our products. Any use of Innaxon products outside of the Authorized Uses requires additional rights from the Licensor.

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