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Nano-formulated aqueous Curcumin solution (sterile) Ready-to-use!

• Curcumin is a yellow pigment present in the spice turmeric (Curcuma longa) that has been associated with anti-oxidant, anti-inflammatory, anti-cancer, anti-viral, and anti-bacterial activities. However, curcumin shows poor absorption, biodistribution, metabolism, and bioavailability.
• To increase the bioavailability, enhance circulation, improve permeability and resistance to metabolic processing several formulations of curcumin have been prepared which include nanoparticles, liposomes, micelles, and phospholipid complexes.

Nano-formulated aqueous Melatonin (sterile) solution. Ready-to-use!

• Melatonin, an evolutionarily ancient derivative of serotonin with hormonal properties, is the main neuroendocrine secretory product of the pineal gland. It regulates circadian rhythmicity and also exerts anti-oxidative, anti-inflammatory, immunomodulatory, and anti-tumor capacities.
• Melatonin levels in individuals increase from birth and peak around puberty. Its synthesis and levels decline in middle-aged and most elderly individuals along with a simultaneous reduction in the urinary excretion of its metabolites.
• Moreover, it stimulates antioxidant defense systems in the brain. The decline in melatonin production in aged individuals is itself a significant factor that may contribute to age-related neurodegenerative disease processes and has been suggested as one of the primary reasons for the development of Alzheimer Disease (AD).
• Melatonin exerts antibacterial activities not only on classic gram-negative and -positive bacteria, but also on members of other bacterial groups, such as Mycobacterium tuberculosis. In recent years, an increasing number of studies have described the anticancer effects of melatonin.
• Melatonin is also a mitophagy regulator. It may exert an essential effect on mitochondrial physiology and facilitates mitochondrial function. A central mechanism by which melatonin protects mitochondria is by restoring the mitochondrial membrane potential (MMP) through blocking mitochondrial permeability transition pore (mPTP) opening under stress and activating uncoupling proteins (UCPs) to marginally decrease MMP under normal conditions.

Nano-formulated aqueous Metformin (sterile) solution. Ready-to-use!

• Metformin is an antihyperglycemic agent of the biguanide class, used for the management of type II diabetes and is currently prescribed to at least 120 million people worldwide.
• AMPK activator
• Mitochondrial electron transport chain complex I inhibitor, reducing mitochondrial reactive oxygen species (ROS).
• Antidiabetic and anti-hyperglycemic agent that reduces blood glucose levels, improves insulin sensitivity, and decreases insulin resistance.
• Insulin sensitizer in non-alcoholic fatty liver disease (NAFLD).
• Increases plasma concentrations of the glucose-lowering gut incretin hormone glucagon-like peptide-1 (GLP-1), which may contribute to metformin’s glucose-lowering effect.
• Anticancer agent with antiproliferative and proapoptotic activity in cancer cell lines.
• Autophagy activator
• Targets brown adipose tissue (BAT) in vivo and reduces oxygen consumption.
• Anti-inflammatory agent by inhibition of nuclear factor κB (NF-κB) via AMPK-dependent and independent pathways.  Also described to inhibit NLRP3 inflammasome activation, subsequent caspase-1 cleavage and interleukin-1β secretion.
• Since the emergence of SARS-CoV-2, Metformin has been investigated as a prophylactic agent for the prevention of COVID-19.

Nano-formulated aqueous Oxyresveratrol (sterile) solution: Ready-to-use!

• Naturally occurring analogue of resveratrol.
• Potent antioxidant and free-radical scavenger.
• Neuroprotective activity against cerebral ischemia and against traumatic injury.
• Apoptosis inhibitor in transient cerebral ischemia.
• Inhibitor of viral DNA replication and late viral protein synthesis
• Depigmenting by effectively inhibiting tyrosinase activity, which catalyzes the rate-limiting step
• in synthesizing melanin pigments.
• Anti-inflammatory by inhibition of iNOS expression through down-regulation of NF-kB binding activity and significant inhibition of COX-2 activity.
• Anti-hyperlipidaemic agent

Nano-formulated aqueous Resveratrol (sterile) solution: Ready-to-use!

• Potent phenolic antioxidant found in grapes and red wine.
• Eicosanoid synthesis and platelet aggregation inhibitor
• Chemopreventive
• Specific inhibitor of cyclooxygenase-1 (COX-1)
• Anti-inflammatory
• Anticancer and antiproliferative compound
• Apoptosis and Autophagy inducer
• Potent SIRT1 (sirtuin 1) activator
• Senescence modulator
• Cardioprotective and neuroprotective
• Adipogenesis inhibitor

Nano-formulated aqueous Umifenorvir (sterile) solution: Ready-to-use!

• Umifenovir (Arbidol) is known to have broad-spectrum anti-viral activity and has earlier been approved in China and Russia for treating influenza, SARS, and Lassa viruses. It has been tested in multiple clinical studies as a candidate for use as an anti-COVID19 therapeutic and has been suggested to act at the entry stage and at the post-entry stages by preventing viral attachment and inhibiting the release of virus particles from intracellular vesicles, respectively.

• In a recent phase III, clinical study Umifenovir met the primary and secondary endpoint criteria. It has been shown to efficacious, safe and well-tolerated at the tested dosage.

Nano-formulated aqueous Dexamethasone (sterile) solution: Ready-to-use!

• Dexamethasone, developed in 1957 and granted FDA approval in 1958, is a corticosteroid structurally similar to hydrocortisone and prednisolone.
• Dexamethasone is used to treat conditions including: endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, and edematous and most recently COVID-19.

Nano-formulated aqueous Ambroxol (sterile) solution: Ready-to-use!

• Ambroxol is a mucolytic agent used in the treatment of respiratory diseases. Ambroxol is a basic (pKa = 9.01) cationic drug with lipophilic properties (logP = 2.9), enabling it to act as a lysosomotropic agent. In addition, ambroxol exhibits a novel mechanism by accumulating in lamellar bodies and acting as a lysosomal secretagogue.
• A wide range of pharmacological effects of ambroxol have been confirmed, including mucus regulation, anti-inflammatory, reduction of arachidonic acid metabolites and pro-inflammatory cytokines, and antioxidant properties. In addition, ambroxol aids in the enhancement of local defence molecules involved in respiratory viral replication.
• Ambroxol is a sodium channel blocker and mucolytic agent with antioxidant, anti-viral and anti-inflammatory properties. Inhibits tetrodotoxin (TTX)-resistant channels more potently than TTX-sensitive subtypes. Inhibits release of histamine, leukotrienes and cytokines from human leukocytes and mast cells. Inhibits viral replication and improves survival rate of mice infected with influenza (H3N2) virus. It is a candidate for use as an anti-COVID19 therapeutic.