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NEW! Lipodisq® Formulation Services
NEW! Lipodisq® Formulation Services
NEW! Lipodisq® Formulation Services
NEW! Lipodisq® Formulation Services
NEW! Lipodisq® Formulation Services

NEW! Lipodisq® Formulation Services

Please contact Innaxon for more information: info@innaxon.com

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Lipodisq® Technology

Malvern Cosmeceutics Ltd has developed a proprietary solubilisation technology known as Lipodisq®, for use in cosmetic and pharmaceutical industries.

The delivery platform is based upon biodegradable nanoparticles known as Lipodisq® which are around 10-40 nm in size.  These minute structures spontaneously assemble to carry target compounds deep into the outer layer of the skin from where the active can easily be released and penetrate into deeper tissues.
The Lipodisq® nanoparticles trapped in the outer layers then degrade into materials present in nutritional or food products. The company has obatined extensive patent protection of its drug delivery system.
Brand Malvern Cosmeceutics

Product Data Sheets

 IAX-100-001 Lipid A from S. minnesota R595 (Re) TLRpureTM Sterile Solution
 IAX-100-002 MPLA from S. minnesota R595 (Re) TLRpureTM Sterile Solution
 IAX-100-003 MPLA from E coli R515 (Re) TLRpureTM Sterile Solution
 IAX-100-004 Lipid A from E. coli R515 (Re) TLRpureTM Sterlie Solution
 IAX-100-006 LPS from E. coli O8:K27 (S-form) TLRpureTM Sterile Solution
 IAX-100-007 LPS from E. coli R515 (Re) TLRpureTM Sterile Solution 
 IAX-100-008 LPS from S. minnesota R595 (Re) TLRpureTM Sterile Solution
 IAX-100-009 LPS (Universal) from S. abortus equi (S-form) TLRpureTM Sterile Solution
 IAX-100-009B LPS from S. abortus equi (S-form) Biotin TLRpureTM Sterile Solution
 IAX-100-010 LPS from E. coli EH100 (Ra) TLRpureTM Sterile Solution
 IAX-100-011 LPS from S. typhimurium (S-form) TLRpureTM Sterile Solution
 IAX-100-012 LPS from E. coli O111:B4 (S-form) TLRpureTM Sterile Solution
 IAX-100-013 LPS from E. coli O55:B5 (S-form) TLRpureTM Sterile Solution
 IAX-100-014 LPS from E. coli J5 (Rc) TLRpureTM Sterile Solution
 IAX-100-015 LPS from S. minnesota R345 (Rb) TLRpureTM Sterile Solution
 IAX-100-016 LPS from S. minnesota R60 (Ra) TLRpureTM Sterile Solution
 IAX-100-017 LPS from S. minnesota R5 (Rc) TLRpureTM Sterile Solution
 IAX-100-018 LPS from S. minnesota R7 (Rd1) TLRpureTM Sterile Solution
 IAX-100-019 LPS from S. enteritidis (S-form) TLRpureTM Sterile Solution
 IAX-100-020 LPS from S. minnesota (S-form) TLRpureTM Sterile Solution
 IAX-100-021 LPS from S. minnesota R3 (Rd2) TLRpureTM Sterile Solution

 IAX-200-001 ODN 1668 (Type B) Endotoxin-free (sterile)
 IAX-200-002 ODN 1826 (Type B) Endotoxin-free (sterile)
 IAX-200-003 ODN 1585 (Type A) Endotoxin-free (sterile)
 IAX-200-004 ODN M362 (Type C) Endotoxin-free (sterile)
 IAX-200-005 ODN 2216 (Type A) Endotoxin-free (sterile)
 IAX-200-006 ODN 2006 (Type B) Endotoxin-free (sterile)
​​​​​​​ IAX-200-007 ODN 2395 (Type C) Endotoxin-free (sterile)

​​​​​​​ IAX-200-050 iODN 2088 (Class I) Endotoxin-free (sterile)
​​​​​​​ IAX-200-051 iODN (ttaggg)4 (Class II) Endotoxin-free (sterile)
​​​​​​​ IAX-200-052 G-type iODN (Class I) Endotoxin-free (sterile)
​​​​​​​ IAX-200-053 Mini-iODN (Class I) Endotoxin-free (sterile)
​​​​​​​ IAX-200-054 Mega-iODN (Class I/ll) Endotoxin-free (sterile)
​​​​​​​ IAX-200-055 Duo-iODN (Class I) Endotoxin-free (sterile)
​​​​​​​ IAX-200-056 TLR7-iODN (inhibitory ODN) Endotoxin-free (sterile)

​​​​​​​ IAX-200-101 Trehalose 6,6’-dimycolate [Cord Factor] Endotoxin-free (sterile)

​​​​​​​ IAX-200-200 ODN 1720 (Control for ODN 1668) Endotoxin-free (sterile)
​​​​​​​ IAX-200-201 ODN 2138 (Control for ODN 1826) Endotoxin-free (sterile)
​​​​​​​ IAX-200-202 Neutral-ODN (Control for iODNs) Endotoxin-free (sterile)
​​​​​​​ IAX-200-203 ODN 2118 (Control for ODN 1585) Endotoxin-free (sterile)
​​​​​​​ IAX-200-204 ODN M383 (Control for ODN M362) Endotoxin-free (sterile)
​​​​​​​ IAX-200-205 ODN 2243 (Control for ODN 2216) Endotoxin-free (sterile)
​​​​​​​ IAX-200-206 ODN 2137 (Control for ODN 2006) Endotoxin-free (sterile)
​​​​​​​ IAX-200-208 CTRL2-ODN (Control for iODN and CpG-ODNs) Endotoxin-free (sterile)

​​​​​​​ IAX-400-002 Anti-TLR4 (Human) mAb (Blocking)
​​​​​​​ IAX-400-003 Anti-TLR4 (Human) mAb (2EII)
​​​​​​​ IAX-400-004 Anti-TLR4 (human) mAb (28H7)

​​​​​​​ IAX-600-001 IAXO-101
​​​​​​​ IAX-600-002 IAXO-102
​​​​​​​ ​​​​​​​IAX-600-003 IAXO-103
​​​​​​​ IAX-600-004 IAXO-201 (Control for IAXO-102)
​​​​​​​ IAX-600-005 IAXO-202 (Control for IAXO-101 and IAXO-103)

​​​​​​​ IAX-700-001 Argania Spinosa Kernel Oil (natural) (pure)

​​​​​​​ IAX-700-100 Lipodisq Control (sterile)
​​​​​​​ IAX-700-101 Nano-Curcumin Lipodisq (sterile)
​​​​​​​ IAX-700-102 Melatonin Lipodisq (sterile)
​​​​​​​ IAX-700-103 Metformin Lipodisq (sterile)
​​​​​​​ IAX-700-104 Oxyresveratrol Lipodisq (sterile)
​​​​​​​ IAX-700-105 Resveratrol Lipodisq (sterile)
​​​​​​​ IAX-700-106 Umifenovir Lipodisq (sterile)
​​​​​​​ IAX-700-107 Dexamethasone Lipodisq (sterile)
​​​​​​​ IAX-700-108 Ambroxol Lipodisq (sterile)
 
​​​​​​​ IAX-900-001 PBS Endotoxin-free (sterile)
​​​​​​​ IAX-900-002 ddWater Endotoxin-free (sterile)
​​​​​​​ ​​​​​​​IAX-900-003 Physiological Saline [NaCl 0.9%] Endotoxin-free (sterile)
​​​​​​​ IAX-900-004 PBS with EDTA Endotoxin-free (sterile)
​​​​​​​ IAX-900-005 TRIS with EDTA (TE Buffer) (100x)​​​​​​​
​​​​​​

Safety Data Sheets

​​​​​​​ IAX-100-001 Lipid A from S. minnesota R595 (Re) TLRpureTM Sterile Solution
​​​​​​​ IAX-100-002 MPLA from S. minnesota R595 (Re) TLRpureTM Sterile Solution
​​​​​​​ IAX-100-003 MPLA from E coli R515 (Re) TLRpureTM Sterile Solution
​​​​​​​ IAX-100-004 Lipid A from E. coli R515 (Re) TLRpureTM Sterlie Solution
​​​​​​​ IAX-100-006 LPS from E. coli O8:K27 (S-form) TLRpureTM Sterile Solution
​​​​​​​ IAX-100-007 LPS from E. coli R515 (Re) TLRpureTM TLRpureTM Sterile Solution
​​​​​​​ IAX-100-008 LPS from S. minnesota R595 (Re) TLRpureTM Sterile Solution
​​​​​​​ IAX-100-009 LPS (Universal) from S. abortus equi (S-form) TLRpureTM Sterile Solution
​​​​​​​ IAX-100-009B LPS from S. abortus equi (S-form) Biotin TLRpureTM Sterile Solution
​​​​​​​ IAX-100-010 LPS from E. coli EH100 (Ra) TLRpureTM TLRpureTM Sterile Solution
​​​​​​​ IAX-100-011 LPS from S. typhimurium (S-form) TLRpureTM Sterile Solution
​​​​​​​ IAX-100-012 LPS from E. coli O111:B4 (S-form) TLRpureTM Sterile Solution
​​​​​​​ IAX-100-013 LPS from E. coli O55:B5 (S-form) TLRpureTM Sterile Solution
​​​​​​​ IAX-100-014 LPS from E. coli J5 (Rc) TLRpureTM Sterile Solution
​​​​​​​ IAX-100-015 LPS from S. minnesota R345 (Rb) TLRpureTM Sterile Solution
​​​​​​​ IAX-100-016 LPS from S. minnesota R60 (Ra) TLRpureTM Sterile Solution
​​​​​​​ IAX-100-017 LPS from S. minnesota R5 (Rc) TLRpureTM Sterile Solution
​​​​​​​ IAX-100-018 LPS from S. minnesota R7 (Rd1) TLRpureTM Sterile Solution
​​​​​​​ ​​​​​​​IAX-100-019 LPS from S. enteritidis (S-form) TLRpureTM Sterile Solution
​​​​​​​ IAX-100-020 LPS from S. minnesota (S-form) TLRpureTM Sterile Solution
​​​​​​​ IAX-100-021 LPS from S. minnesota R3 (Rd2) TLRpureTM Sterile Solution

​​​​​​​ IAX-200-001 ODN 1668 (Type B) Endotoxin-free (sterile)
​​​​​​​ IAX-200-002 ODN 1826 (Type B) Endotoxin-free (sterile)
​​​​​​​ IAX-200-003 ODN 1585 (Type A) Endotoxin-free (sterile)
​​​​​​​ IAX-200-004 ODN M362 (Type C) Endotoxin-free (sterile)
​​​​​​​ IAX-200-005 ODN 2216 (Type A) Endotoxin-free (sterile)
​​​​​​​ IAX-200-006 ODN 2006 (Type B) Endotoxin-free (sterile)
​​​​​​​ IAX-200-007 ODN 2395 (Type C) Endotoxin-free (sterile)

​​​​​​​​​​​​​​ IAX-200-050 iODN 2088 (Class I) Endotoxin-free (sterile)
​​​​​​​ IAX-200-051 iODN (ttaggg)4 (Class II) Endotoxin-free (sterile)
​​​​​​​ IAX-200-052 G-type iODN (Class I) Endotoxin-free (sterile)
​​​​​​​ IAX-200-053 Mini-iODN (Class I) Endotoxin-free (sterile)
​​​​​​​ IAX-200-054 Mega-iODN (Class I/ll) Endotoxin-free (sterile)
​​​​​​​ IAX-200-055 Duo-iODN (Class I) Endotoxin-free (sterile)
​​​​​​​ IAX-200-056 TLR7-iODN (inhibitory ODN) Endotoxin-free (sterile)

​​​​​​​ IAX-200-101 Trehalose 6,6’-dimycolate [Cord Factor] Endotoxin-free (sterile)

​​​​​​​ IAX-200-200 ODN 1720 (Control for ODN 1668) Endotoxin-free (sterile)
​​​​​​​ IAX-200-201 ODN 2138 (Control for ODN 1826) Endotoxin-free (sterile)
​​​​​​​ IAX-200-202 Neutral-ODN (Control for iODNs) Endotoxin-free (sterile)
​​​​​​​ IAX-200-203 ODN 2118 (Control for ODN 1585) Endotoxin-free (sterile)
​​​​​​​ IAX-200-204 ODN M383 (Control for ODN M362) Endotoxin-free (sterile)
​​​​​​​ IAX-200-205 ODN 2243 (Control for ODN 2216) Endotoxin-free (sterile)
​​​​​​​ IAX-200-206 ODN 2137 (Control for ODN 2006) Endotoxin-free (sterile)
​​​​​​​ IAX-200-208 CTRL2-ODN (Control for iODN and CpG-ODNs) Endotoxin-free (sterile)

​​​​​​​ IAX-400-002 Anti-TLR4 (Human) mAb (Blocking)
​​​​​​​ IAX-400-003 Anti-TLR4 (Human) mAb (2EII)
​​​​​​​ IAX-400-004 Anti-TLR4 (human) mAb (28H7)

​​​​​​​ IAX-600-001 IAXO-101
​​​​​​​ IAX-600-002 IAXO-102
​​​​​​​ IAX-600-003 IAXO-103
​​​​​​​ IAX-600-004 IAXO-201 (Control for IAXO-102)
​​​​​​​ IAX-600-005 IAXO-202 (Control for IAXO-101 and IAXO-103)

​​​​​​​ IAX-700-001 Argania Spinosa Kernel Oil (natural) (pure)

​​​​​​​ ​​​​​​​IAX-700-100 Lipodisq Control (sterile)
​​​​​​​ IAX-700-101 Nano-Curcumin Lipodisq (sterile)
​​​​​​​ IAX-700-102 Melatonin Lipodisq (sterile)
​​​​​​​ IAX-700-103 Metformin Lipodisq (sterile)
​​​​​​​ IAX-700-104 Oxyresveratrol Lipodisq (sterile)
​​​​​​​ IAX-700-105 Resveratrol Lipodisq (sterile)
​​​​​​​ ​​​​​​​IAX-700-106 Umifenovir Lipodisq (sterile)
​​​​​​​ ​​​​​​​IAX-700-107 Dexamethasone Lipodisq (sterile)
​​​​​​​ IAX-700-108 Ambroxol Lipodisq (sterile)

​​​​​​​ IAX-900-001 PBS Endotoxin-free (sterile)
​​​​​​​ IAX-900-002 ddWater Endotoxin-free (sterile)
​​​​​​​ IAX-900-003 Physiological Saline [NaCl 0.9%] Endotoxin-free (sterile)
​​​​​​​ IAX-900-004 PBS with EDTA Endotoxin-free (sterile)
​​​​​​​ IAX-900-005 TRIS with EDTA (TE Buffer) (100x)​​​​​​​

​​​​​​​

Need additional information?
Please get in touch via email: info@innaxon.com

Related Products

  • LipodisqTM Control Sterile Solution Cat. No. #IAX-700-100

    LipodisqTM Control Sterile Solution Cat. No. #IAX-700-100

    £165.00
    Control LipodisqTM solution. Ready-to-use!
    Cannot be used to formulate / incorporate actives.
    • A nanoparticle (11-40nm) drug delivery system comprising a discoidal phospholipid bilayer membrane stabilised by a chaperone molecule annulus.
    • Internal properties of the phospholipid membrane support the disposition and stabilisation of drug molecule candidates and preserve the native conformation of membrane molecules.
    • The resulting encapsulated actives are rendered water-soluble and specialised for intra-cellular penetration/delivery via endosomal uptake mechanisms.
    • LipodisqTM solutions show a good safety profile and are suitable for in vitro and in vivo investigations.
    • For a customizable biodegradable LipodisqTM version with a higher concentration of actives or an alternative lipid option, contact Innaxon.
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    • Curcumin is a yellow pigment present in the spice turmeric (Curcuma longa) that has been associated with anti-oxidant, anti-inflammatory, anti-cancer, anti-viral, and anti-bacterial activities. However, curcumin shows poor absorption, biodistribution, metabolism, and bioavailability.
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    Melatonin powered by LipodisqTM Sterile Solution Cat. No. #IAX-700-102

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    Nano-formulated aqueous Melatonin (sterile) solution. Ready-to-use!

    • Melatonin, an evolutionarily ancient derivative of serotonin with hormonal properties, is the main neuroendocrine secretory product of the pineal gland. It regulates circadian rhythmicity and also exerts anti-oxidative, anti-inflammatory, immunomodulatory, and anti-tumor capacities.
    • Melatonin levels in individuals increase from birth and peak around puberty. Its synthesis and levels decline in middle-aged and most elderly individuals along with a simultaneous reduction in the urinary excretion of its metabolites.
    • Moreover, it stimulates antioxidant defense systems in the brain. The decline in melatonin production in aged individuals is itself a significant factor that may contribute to age-related neurodegenerative disease processes and has been suggested as one of the primary reasons for the development of Alzheimer Disease (AD).
    • Melatonin exerts antibacterial activities not only on classic gram-negative and -positive bacteria, but also on members of other bacterial groups, such as Mycobacterium tuberculosis. In recent years, an increasing number of studies have described the anticancer effects of melatonin.
    • Melatonin is also a mitophagy regulator. It may exert an essential effect on mitochondrial physiology and facilitates mitochondrial function. A central mechanism by which melatonin protects mitochondria is by restoring the mitochondrial membrane potential (MMP) through blocking mitochondrial permeability transition pore (mPTP) opening under stress and activating uncoupling proteins (UCPs) to marginally decrease MMP under normal conditions.
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    Nano-formulated aqueous Metformin (sterile) solution. Ready-to-use!

    • Metformin is an antihyperglycemic agent of the biguanide class, used for the management of type II diabetes and is currently prescribed to at least 120 million people worldwide.
    • AMPK activator
    • Mitochondrial electron transport chain complex I inhibitor, reducing mitochondrial reactive oxygen species (ROS).
    • Antidiabetic and anti-hyperglycemic agent that reduces blood glucose levels, improves insulin sensitivity, and decreases insulin resistance.
    • Insulin sensitizer in non-alcoholic fatty liver disease (NAFLD).
    • Increases plasma concentrations of the glucose-lowering gut incretin hormone glucagon-like peptide-1 (GLP-1), which may contribute to metformin’s glucose-lowering effect.
    • Anticancer agent with antiproliferative and proapoptotic activity in cancer cell lines.
    • Autophagy activator
    • Targets brown adipose tissue (BAT) in vivo and reduces oxygen consumption.
    • Anti-inflammatory agent by inhibition of nuclear factor κB (NF-κB) via AMPK-dependent and independent pathways.  Also described to inhibit NLRP3 inflammasome activation, subsequent caspase-1 cleavage and interleukin-1β secretion.
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    Nano-formulated aqueous Oxyresveratrol (sterile) solution: Ready-to-use!

    • Naturally occurring analogue of resveratrol.
    • Potent antioxidant and free-radical scavenger.
    • Neuroprotective activity against cerebral ischemia and against traumatic injury.
    • Apoptosis inhibitor in transient cerebral ischemia.
    • Inhibitor of viral DNA replication and late viral protein synthesis
    • Depigmenting by effectively inhibiting tyrosinase activity, which catalyzes the rate-limiting step
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    • Potent phenolic antioxidant found in grapes and red wine.
    • Eicosanoid synthesis and platelet aggregation inhibitor
    • Chemopreventive
    • Specific inhibitor of cyclooxygenase-1 (COX-1)
    • Anti-inflammatory
    • Anticancer and antiproliferative compound
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    • Ambroxol is a sodium channel blocker and mucolytic agent with antioxidant, anti-viral and anti-inflammatory properties. Inhibits tetrodotoxin (TTX)-resistant channels more potently than TTX-sensitive subtypes. Inhibits release of histamine, leukotrienes and cytokines from human leukocytes and mast cells. Inhibits viral replication and improves survival rate of mice infected with influenza (H3N2) virus. It is a candidate for use as an anti-COVID19 therapeutic.
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