Mincle Agonist: TDM [Cord Factor]

General Information

The mycobacterial glycolipid trehalose-6,6’-dimycolate (TDM), also named Cord Factor (CF), is an important regulator of immune responses during Mycobacterium tuberculosis (Mtb) infections. Macrophages recognize TDM through the Mincle receptor and initiate TDM-induced inflammatory responses, leading to lung granuloma formation. controlled use of its cell wall activates macrophages in ways that can be harnessed for therapy. For example, M. bovis Bacille Calmette-Guérin (BCG) is one of the most widely used antitumor adjuvant therapies in humans. 

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