R-type LPS represents the mutant form of bacterial LPS.

• Variable solubility in buffers containing divalent ions: risk of LPS precipitation.
• Extremely potent immunostimulatory agent of TLR4.
• Low dependency for soluble / membrane-bound CD14 or soluble LPS binding protein (LBP).
• LPS of choice for experimental in vitro (cellular assays) applications.

S-type LPS represents the wild-type form of bacterial LPS.

• Excellent solubility in standard buffers including those containing divalent ions.
• Extremely potent immunostimulatory agent of TLR4.
• High dependency for soluble / membrane-bound CD14 or soluble LPS binding protein (LBP).
• LPS of choice for experimental in vivo applications.