iODNs (inhibitory ODNs)

General Information

In recent years several groups have studied the sequence requirements, specificity, signalling pathways and kinetics of the TLR (Toll-like receptor) 9 suppression by inhibitory oligonucleotide motifs, which led to a class of novel inhibitory oligonucleotide (iODNs), that is independent of the previously thought species preference. Subsequently it has been discovered that telomeric DNA repeats (TTAGGG)n can block immune activation by CpG-ODNs. Short, 11–15 base long oligonucleotides were synthesized that were capable of potently inhibiting CpG-stimulation. The optimal inhibitory DNA motif consists of a pyrimidine-rich triplet, preferably CCT, which is positioned 5- to the GGG sequence in a singlestranded DNA molecule. Additionally, both the optimal spacing between the CCT and GGG motifs, as well as their relative order to each other, is of crucial importance for the inhibitory DNA action. Interestingly, although both TLR7/TLR8 ligands and bacterial DNA share the endosomal compartment for receptor binding and signal transduction, certain iODNs (G-type) suppress only TLR9-mediated activation, whereas prototype class I iODN may also interfere with the activation via the TLR7/TLR8 pathway. 

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  • iODN Explorer Set II Endotoxin-free (sterile)

    iODN Explorer Set II Endotoxin-free (sterile)

    £335.29
    Explorer™ Set contains iODN 2088 (Class I) Endotoxin-free (sterile), 100μg (Cat. No.: IAX-200-050-C100). G-type-iODN (Class I) Endotoxin-free (sterile), 100μg (Cat. No.: IAX-200-052-C100). Mini-iODN (Class I) Endotoxin-free (sterile), 100μg (Cat. No.: IAX-200-053-C100). Duo-iODN (Class I) Endotoxin-free (sterile), 100μg (Cat. No.: IAX-200-055-C100). iODN (ttaggg)4 (Class II) Endotoxin-free (sterile), 100μg (Cat. No.: IAX-200-051-C100). Mega-iODN (Class I/II) Endotoxin-free (sterile), 100μg (Cat. No.: IAX-200-054-C100). Negative control for iODN: Neutral-ODN Endotoxin-free (sterile), 100μg (Cat. No.: IAX-200-202-C100). ddWater Endotoxin-free (sterile), 10ml (Cat. No.: IAX-900-002-L010).
  • iODN Explorer Set I Endotoxin-free (sterile)

    iODN Explorer Set I Endotoxin-free (sterile)

    £244.99
    Explorer™ Set contains iODN 2088 (Class I) Endotoxin-free (sterile), 100μg (Cat. No.: IAX-200-050-C100). G-type-iODN (Class I) Endotoxin-free (sterile), 100μg (Cat. No.: IAX-200-052-C100). Mini-iODN (Class I) Endotoxin-free (sterile), 100μg (Cat. No.: IAX-200-053-C100). Duo-iODN (Class I) Endotoxin-free (sterile), 100μg (Cat. No.: IAX-200-055-C100). Negative control for iODN: Neutral-ODN Endotoxin-free (sterile), 100μg (Cat. No.: IAX-200-202-C100). ddWater Endotoxin-free (sterile), 10ml (Cat. No.: IAX-900-002-L010).
Viewing 1 — 4 of 4 items | Page 1 of 1