Featured products

  • Retinoic Acid powered by LipodisqTM Sterile Solution Cat. No. #IAX-700-109

    Retinoic Acid powered by LipodisqTM Sterile Solution Cat. No. #IAX-700-109

    £165.00

    • Vitamin A is a fat-soluble micronutrient necessary for the growth of healthy skin and hair. However, both too little and too much vitamin A has deleterious effects. All-transretinoic acid (ATRA) and retinal are the main active metabolites of vitamin A. Retinoic acid dose-dependently regulates hair follicle stem cells, influencing the functioning of the hair cycle, wound healing, and melanocyte stem cells. Retinoic acid also influences melanocyte differentiation and proliferation in a dose-dependent and temporal manner. Levels of retinoids decline when exposed to ultraviolet irradiation in the skin.

    • All-trans-retinoic acid (ATRA) is effective for preventing cancer and treating skin diseases and acute promyelocytic leukaemia (APL). These pharmacological effects of ATRA are mainly mediated by retinoid X receptors (RXRs) and retinoic acid receptors (RARs). These included two families of receptors, the RAR isotypes (a,b, and g) along with three RXR isotypes (a,b, and g), which bind as RXR/RAR heterodimers to cis-acting response elements of RA target genes to generate a high degree of complexity. • Retinoic acid is used in the treatment of psoriasis, ichthyosis, follicular keratosis, acne, lichen planus, verrucous epidermal nevus, impetigo, vitiligo, lichen psoriasis, the face of pityriasis alba.

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  • DMPC (1,2-Dimyristoyl-sn-glycero-3-phosphocholine) (14:0 PC) Cat. No. #IAX-700-400

    DMPC (1,2-Dimyristoyl-sn-glycero-3-phosphocholine) (14:0 PC) Cat. No. #IAX-700-400

    From: £42.00

    • A nanoparticle (11-40nm) drug delivery system comprising a discoidal phospholipid bilayer membrane stabilised by a chaperone molecular annulus.

    • LipodisqTM polymers are available as 4 defined structures (1:1, 2:1, 3:1 and 4:1 Styrene to Maleic Acid (SMA) rations) each individually operational within a selected pH range for optimal working conditions.

    • Components are batch-tested for LipodisqTM formation using buffer systems available, which are tested for nano-formulated drug analysis by Dynamic Light Scattering (DLS). These buffer solutions are endotoxin-tested and sterile.

    • LipodisqTM formation is highly efficient and nanodiscs show a good safety profile and are suitable for in vitro and in vivo (in experimental animals) investigations.

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  • Lipodisq™ Styrene:Maleic Acid Copolymer 1:1 [SMA-100] Cat. No. #IAX-700-201

    Lipodisq™ Styrene:Maleic Acid Copolymer 1:1 [SMA-100] Cat. No. #IAX-700-201

    £95.00

    • A nanoparticle (11-40nm) drug delivery system comprising a discoidal phospholipid bilayer membrane stabilised by a chaperone molecular annulus.

    • LipodisqTM polymers are available as 4 defined structures (1:1, 2:1, 3:1 and 4:1 Styrene to Maleic Acid (SMA) rations) each individually operational within a selected pH range for optimal working conditions.

    • Components are batch-tested for LipodisqTM formation using buffer systems available, which are tested for nano-formulated drug analysis by Dynamic Light Scattering (DLS). These buffer solutions are endotoxin-tested and sterile.

    • LipodisqTM formation is highly efficient and nanodiscs show a good safety profile and are suitable for in vitro and in vivo (in experimental animals) investigations.

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  • SMA Universal with pH-Selector Cat. No. #IAX-700-205

    SMA Universal with pH-Selector Cat. No. #IAX-700-205

    From: £95.00

    • A nanoparticle (11-40nm) drug delivery system comprising a discoidal phospholipid bilayer • membrane stabilised by a chaperone molecular annulus.

    • All components are batch tested for Lipodisq™ formation using validated buffer systems, which are assessed by Dynamic Light Scattering (DLS) to confirm nano-formulated drug characteristics. The buffer solutions themselves are endotoxin tested and supplied sterile.

    • Lipodisq™ formation is highly efficient and shows a good safety profile, suitable for in vitro and in vivo (in experimental animals) investigations.

    Enables membrane proteins (MP) to be reconstituted within phospholipid membrane mimics
    without the use of mediating detergent. Nanodiscs formed from SMA are also referred to as styrene
    maleic acid lipid particles (SMALP). SMA-lipid particles are formed by directly extracting membrane
    proteins either from native cellular membranes (giving native nanodiscs) or from an intermediary
    MP-reconstituted synthetic membrane system to ultimately form self-assembled discoidal nano-structures
    of a general diameter of 10–12 nm.
    • uSMA requires only a single polymer grade to be used, avoids the need to select several SMA
    grades that each operate only over a narrow pH range
    • uSMA can be tailored to operate over a wide pH range 4.5-8.5 by simple addition of standard
    quantities of pH-Selector™
    • uSMA is insensitive to presence of divalent cations, Ca2+(<10mM) and Mg2+ (<30mM),
    suitable for use with ion pores, ABC transporters and ion sensitive GPCR assemblies
    • uSMA can be modified to form larger particles, reducing direct interactions between the polymer
    chaperone and membrane‑bound proteins
    The ability of SMA to create monodisperse nanodiscs covering a range of particle sizes facilitates
    the reconstitution of oligomeric MPs and MP complexes for analysis by various methods including
    fluorescence microscopy, NMR and single-particle cryo-EM. Lipodisq™ technology is a proprietary
    technology developed by Malvern Cosmeceutics Limited and is subject to granted international patents.
    See: https://lipodisq.com.

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  • Lipodisq™ Styrene:Maleic Acid Copolymer 2:1 [SMA-200] Cat. No. #IAX-700-202

    Lipodisq™ Styrene:Maleic Acid Copolymer 2:1 [SMA-200] Cat. No. #IAX-700-202

    From: £92.00

    • A nanoparticle (11-40nm) drug delivery system comprising a discoidal phospholipid bilayer membrane stabilised by a chaperone molecular annulus.

    • Lipodisq™ polymers are available as 4 defined structures (1:1, 2:1, 3:1 and 4:1 Styrene to Maleic Acid (SMA) rations) each individually operational within a selected pH range for optimal working conditions. • Components are batch-tested for Lipodisq™ formation using buffer systems available, which are tested for nano-formulated drug analysis by Dynamic Light Scattering (DLS). These buffer solutions are endotoxin-tested and sterile.

    • Lipodisq™ formation is highly efficient and nanodiscs show a good safety profile and are suitable for in vitro and in vivo (in expermental animals) investigations.

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  • Lipodisq™ Styrene:Maleic Acid Copolymer 3:1 [SMA-300] Cat. No. #IAX-700-203

    Lipodisq™ Styrene:Maleic Acid Copolymer 3:1 [SMA-300] Cat. No. #IAX-700-203

    From: £92.00

    • A nanoparticle (11-40nm) drug delivery system comprising a discoidal phospholipid bilayer membrane stabilised by a chaperone molecular annulus.

    • Lipodisq™ polymers are available as 4 defined structures (1:1, 2:1, 3:1 and 4:1 Styrene to Maleic Acid (SMA) rations) each individually operational within a selected pH range for optimal working conditions. • Components are batch-tested for Lipodisq™ formation using buffer systems available, which are tested for nano-formulated drug analysis by Dynamic Light Scattering (DLS). These buffer solutions are endotoxin-tested and sterile.

    • Lipodisq™ formation is highly efficient and nanodiscs show a good safety profile and are suitable for in vitro and in vivo (in expermental animals) investigations.

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  • Lipodisq™ Styrene:Maleic Acid Copolymer 4:1 [SMA-400] Cat. No. #IAX-700-204

    Lipodisq™ Styrene:Maleic Acid Copolymer 4:1 [SMA-400] Cat. No. #IAX-700-204

    £92.00

    • A nanoparticle (11-40nm) drug delivery system comprising a discoidal phospholipid bilayer membrane stabilised by a chaperone molecular annulus.

    • Lipodisq™ polymers are available as 4 defined structures (1:1, 2:1, 3:1 and 4:1 Styrene to Maleic Acid (SMA) rations) each individually operational within a selected pH range for optimal working conditions. • Components are batch-tested for Lipodisq™ formation using buffer systems available, which are tested for nano-formulated drug analysis by Dynamic Light Scattering (DLS). These buffer solutions are endotoxin-tested and sterile.

    • Lipodisq™ formation is highly efficient and nanodiscs show a good safety profile and are suitable for in vitro and in vivo (in expermental animals) investigations.

    Add to Cart