IAXO-202 (Control for IAXO-101 / IAXO-103) (synthetic)

The novel IAXO classes of glycolipid and benzylammonium lipids are synthetic TLR4/CD14 ligands with TLR4 modulating activities in vitro, and conferring protection against TLR4/CD14-mediated tissue damage and inflammation in vivo.
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Methyl 6-O-cyclopentyl-2,3-di-O-tetradecyl-α-D-Glucopyranoside

Persistent inflammation has been implicated in the pathogenesis not only of diverse chronic diseases such as neuropathic pain, atherosclerosis, chronic hepatitis, and abdominal aortic aneurysm, but also acute organ failure, cardiac infarct and stroke.

The Toll-like receptor (TLR) family members are key contributors to these pro- inflammatory conditions. These pattern recognition receptors respond to molecular patterns in components of bacteria and viruses. In addition to their role in detecting pathogen associated molecular patterns (PAMPs), TLRs can also sense endogenous danger (or tissue damage) associated molecular patterns (DAMPs) and have been implicated in perpetuating inflammatory cascades in the absence of invading microbes or other pathogens.

TLR4’s well-known key role in orchestrating innate and adaptive immune response to Gram-negative bacteria now extends into the area of mediating auto-inflammation and tissue repair and re-modelling.

IAXO compounds hold considerable promise in pharmacological settings, where inhibition of sterile (auto-) inflammation is desired, without compromising TLR4’s key role in the defense of pathogens. CD14-dependent and independent TLR4 activation in the central nervous system by endogenous factors has been recently related to a wide array of inflammatory neurological diseases such as amyotrophic lateral sclerosis and Alzheimer’s disease.
 


Product Specific References

[1] Glycolipids and benzylammonium lipids as novel antisepsis agents: synthesis and biological characterization. Piazza M, et al. J. Med. Chem. (2009); 52:1209
[2] Inhibition of lipid a stimulated activation of human dendritic cells and macrophages by amino and hydroxylamino monosaccharides.
Peri F, et al. Angew .Chem. (2007); 46:3308
[3] Evidence of a specific interaction between new synthetic antisepsis agents and CD14. Piazza M, et al. Biochemistry (2009); 48:12337
[4] Therapeutic targeting of innate immunity with Toll-like receptor 4 (TLR4) antagonists. Peri F, Piazza M. Biotechnol. Adv. (2012); 30:251 REVIEW
[5] Synthetic molecules and functionalized nanoparticles targeting the LPS-TLR4 signaling: A new generation of immunotherapeutics. Peri F, Calabrese V, Piazza M, Cighetti R.Pure Appl. Chem. (2012); 84:97 REVIEW
 


Active Compounds
IAXO-101 and IAXO-103

Brand Innaxon
Code IAX-600-005-M001
Product Data Sheets


 Lipid A from E. coli R515 (Re) TLRpureTM Sterlie Solution Product Data Sheet
 Lipid A from S. minnesota R595 (Re) TLRpureTM Sterile Solution Product Data Sheet
 MPLA from E coli R515 (Re) TLRpureTM Sterile Solution Product Data Sheet
 
MPLA from S. minnesota R595 (Re) TLRpureTM Sterile Solution Product Data Sheet

 LPS from E. coli O8:K27 (S-form) TLRpureTM Sterile Solution Product Data Sheet
 LPS from E. coli EH100 (Ra) TLRpureTM Sterile Solution Product Data Sheet
 LPS from E. coli O111:B4 (S-form) TLRpureTM Sterile Solution Product Data Sheet
 LPS from E. coli O55:B5 (S-form) TLRpureTM Sterile Solution Product Data Sheet
 LPS from E. coli J5 (Rc) TLRpureTM Sterile Solution Product Data Sheet

TLR4 Agonist (E. coli) Explorer Set I TLRpureTM Product Data Sheet
 TLR4 Agonist (E. coli) Explorer Set II TLRpureTM Product Data Sheet


 LPS (Universal) from S. abortus equi (S-form) TLRpureTM Sterile Solution Product Data Sheet
 LPS from S. abortus equi (S-form) Biotin TLRpureTM Sterile Solution Product Data Sheet
 LPS from S. minnesota R595 (Re) TLRpureTM Sterile Solution Product Data Sheet
 LPS from S. enteritidis (S-form) TLRpureTM Sterile Solution Product Data Sheet
 LPS from S. minnesota R345 (Rb) TLRpureTM Sterile Solution Product Data Sheet
 LPS from S. minnesota R60 (Ra) TLRpureTM Sterile Solution Product Data Sheet
 LPS from S. minnesota R7 (Rd1) TLRpureTM Sterile Solution Product Data Sheet
 LPS from S. minnesota (S-form) TLRpureTM Sterile Solution Product Data Sheet
 LPS from S. typhimurium (S-form) TLRpureTM Sterile Solution Product Data Sheet

 TLR4 Agonist (Salmonella) Explorer Set I TLRpureTM Product Data Sheet
 TLR4 Agonist (Salmonella) Explorer Set II TLRpureTM Product Data Sheet


 iODN 2088 (Class I) Endotoxin-free (sterile) Product Data Sheet
iODN (ttaggg)4 (Class II) Endotoxin-free (sterile) Product Data Sheet
G-type iODN (Class I) Endotoxin-free (sterile) Product Data Sheet
Duo-iODN (Class I) Endotoxin-free (sterile) Product Data Sheet
Mini-iODN (Class I) Endotoxin-free (sterile) Product Data Sheet

Mega-iODN (Class I/ll) Endotoxin-free (sterile) Product Data Sheet

 iODN Explorer Set I Endotoxin-free (sterile) Product Data Sheet

Neutral-ODN (Control for iODNs) Endotoxin-free (sterile) Product Data Sheet

 ODN 2216 (Type A) Endotoxin-free (sterile) Product Data Sheet
ODN 2006 (Type B) Endotoxin-free (sterile) Product Data Sheet
 ODN 2395 (Type C) Endotoxin-free (sterile) Product Data Sheet
ODN 1585 (Type A) Endotoxin-free (sterile) Product Data Sheet
ODN 1668 (Type B) Endotoxin-free (sterile) Product Data Sheet
 ODN 1826 (Type B) Endotoxin-free (sterile) Product Data Sheet
ODN M362 (Type C) Endotoxin-free (sterile) Product Data Sheet


TLR9 Agonist (human) Explorer Set Endotoxin-free (sterile) Product Data Sheet
TLR9 Agonist (mouse) Explorer Set Endotoxin-free (sterile) Product Data Sheet

ODN 2243 (Control for ODN 2216) Endotoxin-free (sterile) Product Data Sheet
ODN 2137 (Control for ODN 2006) Endotoxin-free (sterile) Product Data Sheet
 ODN 2118 (Control for ODN 1585) Endotoxin-free (sterile) Product Data Sheet
ODN 1720 (Control for ODN 1668) Endotoxin-free (sterile) Product Data Sheet
ODN 2138 (Control for ODN 1826) Endotoxin-free (sterile) Product Data Sheet
ODN M383 (Control for ODN M362) Endotoxin-free (sterile) Product Data Sheet

 IAXO-101 Product Data Sheet
 IAXO-102 Product Data Sheet
 IAXO-103 Product Data Sheet


PBS Endotoxin-free (sterile) Product Data Sheet
Physiological Saline [Sodium Chloride 0.9%] Endotoxin-free (sterile) Product Data Sheet
 ddWater Endotoxin-free (sterile) Product Data Sheet


 Argania Spinosa Kernel Oil (natural) (pure) Product Data Sheet

 Trehalose 6,6’-dimycolate [Cord Factor] Endotoxin-free (sterile) Product Data Sheet

 

Material Safety Data Sheets (MSDS)
 

 Lipid A from E. coli R515 (Re) TLRpureTM Sterlie Solution MSDS
 Lipid A from S. minnesota R595 (Re) TLRpureTM Sterile Solution MSDS
 MPLA from E coli R515 (Re) TLRpureTM Sterile Solution MSDS
 
MPLA from S. minnesota R595 (Re) TLRpureTM Sterile Solution MSDS

 LPS from E. coli O8:K27 (S-form) TLRpureTM Sterile Solution MSDS
 LPS from E. coli EH100 (Ra) TLRpureTM Sterile Solution MSDS
 LPS from E. coli O111:B4 (S-form) TLRpureTM Sterile Solution MSDS
 LPS from E. coli O55:B5 (S-form) TLRpureTM Sterile Solution MSDS
 LPS from E. coli J5 (Rc) TLRpureTM Sterile Solution MSDS


TLR4 Agonist (E. coli) Explorer Set I TLRpureTM MSDS
 TLR4 Agonist (E. coli) Explorer Set II TLRpureTM MSDS


 LPS (Universal) from S. abortus equi (S-form) TLRpureTM Sterile Solution MSDS
 LPS from S. abortus equi (S-form) Biotin TLRpureTM Sterile Solution MSDS
 LPS from S. minnesota R595 (Re) TLRpureTM Sterile Solution MSDS
 LPS from S. enteritidis (S-form) TLRpureTM Sterile Solution MSDS
 LPS from S. minnesota R345 (Rb) TLRpureTM Sterile Solution MSDS
 LPS from S. minnesota R60 (Ra) TLRpureTM Sterile Solution MSDS
 LPS from S. minnesota R7 (Rd1) TLRpureTM Sterile Solution MSDS
 LPS from S. minnesota (S-form) TLRpureTM Sterile Solution MSDS
 LPS from S. typhimurium (S-form) TLRpureTM Sterile Solution MSDS

 TLR4 Agonist (Salmonella) Explorer Set I TLRpureTM MSDS
 TLR4 Agonist (Salmonella) Explorer Set II TLRpureTM MSDS


 iODN 2088 (Class I) Endotoxin-free (sterile) MSDS
iODN (ttaggg)4 (Class II) Endotoxin-free (sterile) MSDS
G-type iODN (Class I) Endotoxin-free (sterile) MSDS
Duo-iODN (Class I) Endotoxin-free (sterile) MSDS
Mini-iODN (Class I) Endotoxin-free (sterile) MSDS

Mega-iODN (Class I/ll) Endotoxin-free (sterile) MSDS

 iODN Explorer Set I Endotoxin-free (sterile) MSDS

Neutral-ODN (Control for iODNs) Endotoxin-free (sterile) MSDS

 ODN 2216 (Type A) Endotoxin-free (sterile) MSDS
ODN 2006 (Type B) Endotoxin-free (sterile) MSDS
 ODN 2395 (Type C) Endotoxin-free (sterile) MSDS
ODN 1585 (Type A) Endotoxin-free (sterile) MSDS
ODN 1668 (Type B) Endotoxin-free (sterile) MSDS
 ODN 1826 (Type B) Endotoxin-free (sterile) MSDS
ODN M362 (Type C) Endotoxin-free (sterile) MSDS



TLR9 Agonist (human) Explorer Set Endotoxin-free (sterile) MSDS
TLR9 Agonist (mouse) Explorer Set Endotoxin-free (sterile) MSDS

ODN 2243 (Control for ODN 2216) Endotoxin-free (sterile) MSDS
ODN 2137 (Control for ODN 2006) Endotoxin-free (sterile) MSDS
 ODN 2118 (Control for ODN 1585) Endotoxin-free (sterile) MSDS
ODN 1720 (Control for ODN 1668) Endotoxin-free (sterile) MSDS
ODN 2138 (Control for ODN 1826) Endotoxin-free (sterile) MSDS
ODN M383 (Control for ODN M362) Endotoxin-free (sterile) MSDS


IAXO-101 MSDS
IAXO-102 MSDS
IAXO-103 MSDS


PBS Endotoxin-free (sterile) MSDS
Physiological Saline [Sodium Chloride 0.9%] Endotoxin-free (sterile) MSDS
ddWater Endotoxin-free (sterile) MSDS


Argania Spinosa Kernel Oil (natural) (pure) MSDS

Trehalose 6,6’-dimycolate [Cord Factor] Endotoxin-free (sterile) MSDS
 



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