IAXO-201 (Control for IAXO-102) (synthetic) Cat. No. #IAX-600-004

The novel IAXO classes of glycolipid and benzylammonium lipids are synthetic TLR4/CD14 ligands with TLR4 modulating activities in vitro, and conferring protection against TLR4/CD14-mediated tissue damage and inflammation in vivo.
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Methyl 6-deoxy-6-(methoxyamino)-2,3-di-O-tetradecyl-α-D-glucopyranoside

Cpd. 4 [Ref. 1], Cpd.10 [Ref. 2], Cpd. 6 [4], control small molecule (synthetic) [Ref. 5].

Persistent inflammation has been implicated in the pathogenesis not only of diverse chronic diseases such as neuropathic pain, atherosclerosis, chronic hepatitis, and abdominal aortic aneurysm, but also acute organ failure, cardiac infarct and stroke.

The Toll-like receptor (TLR) family members are key contributors to these pro- inflammatory conditions. These pattern recognition receptors respond to molecular patterns in components of bacteria and viruses. In addition to their role in detecting pathogen associated molecular patterns (PAMPs), TLRs can also sense endogenous danger (or tissue damage) associated molecular patterns (DAMPs) and have been implicated in perpetuating inflammatory cascades in the absence of invading microbes or other pathogens.

TLR4’s well-known key role in orchestrating innate and adaptive immune response to Gram-negative bacteria now extends into the area of mediating auto-inflammation and tissue repair and re-modelling.

IAXO compounds hold considerable promise in pharmacological settings, where inhibition of sterile (auto-) inflammation is desired, without compromising TLR4’s key role in the defense of pathogens. CD14-dependent and independent TLR4 activation in the central nervous system by endogenous factors has been recently related to a wide array of inflammatory neurological diseases such as amyotrophic lateral sclerosis and Alzheimer’s disease.
 


Product Specific References

[1] Glycolipids and benzylammonium lipids as novel antisepsis agents: synthesis and biological characterization. Piazza M, et al. J. Med. Chem. (2009); 52:1209
[2] Inhibition of lipid a stimulated activation of human dendritic cells and macrophages by amino and hydroxylamino monosaccharides. Peri F, et al. Angew .Chem. (2007); 46:3308
[3] Evidence of a specific interaction between new synthetic antisepsis agents and CD14. Piazza M, et al. Biochemistry (2009); 48:12337
[4] Therapeutic targeting of innate immunity with Toll-like receptor 4 (TLR4) antagonists. Peri F, Piazza M. Biotechnol. Adv. (2012); 30:251 REVIEW
[5] Synthetic molecules and functionalized nanoparticles targeting the LPS-TLR4 signaling: A new generation of immunotherapeutics. Peri F, Calabrese V, Piazza M, Cighetti R. Pure Appl. Chem. (2012); 84:97 REVIEW
 


Active Compound
IAXO-102


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Literature
Product Data Sheets
Safety Data Sheets

Brand Innaxon
Code IAX-600-004-M001

Product Data Sheets

 IAX-100-001 Lipid A from S. minnesota R595 (Re) TLRpureTM Sterile Solution
 IAX-100-002 MPLA from S. minnesota R595 (Re) TLRpureTM Sterile Solution
 IAX-100-003 MPLA from E coli R515 (Re) TLRpureTM Sterile Solution
 IAX-100-004 Lipid A from E. coli R515 (Re) TLRpureTM Sterlie Solution

 IAX-100-006 LPS from E. coli O8:K27 (S-form) TLRpureTM Sterile Solution
 IAX-100-007 LPS from E. coli R515 (Re) Sterile Solution 
 IAX-100-008 LPS from S. minnesota R595 (Re) TLRpureTM Sterile Solution
 IAX-100-009 LPS (Universal) from S. abortus equi (S-form) TLRpureTM Sterile Solution
 IAX-100-009B LPS from S. abortus equi (S-form) Biotin TLRpureTM Sterile Solution
 IAX-100-010 LPS from E. coli EH100 (Ra) TLRpureTM Sterile Solution
 IAX-100-011 LPS from S. typhimurium (S-form) TLRpureTM Sterile Solution
 IAX-100-012 LPS from E. coli O111:B4 (S-form) TLRpureTM Sterile Solution
 IAX-100-013 LPS from E. coli O55:B5 (S-form) TLRpureTM Sterile Solution
 IAX-100-014 LPS from E. coli J5 (Rc) TLRpureTM Sterile Solution
 IAX-100-015 LPS from S. minnesota R345 (Rb) TLRpureTM Sterile Solution
 IAX-100-016 LPS from S. minnesota R60 (Ra) TLRpureTM Sterile Solution
 IAX-100-017 LPS from S. minnesota R5 (Rc) Sterile Solution
 IAX-100-018 LPS from S. minnesota R7 (Rd1) TLRpureTM Sterile Solution
 IAX-100-019 LPS from S. enteritidis (S-form) TLRpureTM Sterile Solution
 IAX-100-020 LPS from S. minnesota (S-form) TLRpureTM Sterile Solution
 IAX-100-021 LPS from S. minnesota R3 (Rd2) Sterile Solution

 IAX-200-001 ODN 1668 (Type B) Endotoxin-free (sterile)
 IAX-200-002 ODN 1826 (Type B) Endotoxin-free (sterile)
 IAX-200-003 ODN 1585 (Type A) Endotoxin-free (sterile)
 IAX-200-004 ODN M362 (Type C) Endotoxin-free (sterile)
 IAX-200-005 ODN 2216 (Type A) Endotoxin-free (sterile)
 IAX-200-006 ODN 2006 (Type B) Endotoxin-free (sterile)
 IAX-200-007 ODN 2395 (Type C) Endotoxin-free (sterile)

 IAX-200-050 iODN 2088 (Class I) Endotoxin-free (sterile)
​​​​​​​ IAX-200-051 iODN (ttaggg)4 (Class II) Endotoxin-free (sterile)
​​​​​​​ IAX-200-052 G-type iODN (Class I) Endotoxin-free (sterile)
​​​​​​​ IAX-200-053 Mini-iODN (Class I) Endotoxin-free (sterile)
​​​​​​​ IAX-200-054 Mega-iODN (Class I/ll) Endotoxin-free (sterile)
​​​​​​​ IAX-200-055 Duo-iODN (Class I) Endotoxin-free (sterile)
​​​​​​​ IAX-200-056 TLR7-iODN (inhibitory ODN) Endotoxin-free (sterile)

​​​​​​​ IAX-200-101 Trehalose 6,6’-dimycolate [Cord Factor] Endotoxin-free (sterile)

​​​​​​​ IAX-200-200 ODN 1720 (Control for ODN 1668) Endotoxin-free (sterile)
​​​​​​​ IAX-200-201 ODN 2138 (Control for ODN 1826) Endotoxin-free (sterile)
​​​​​​​ IAX-200-202 Neutral-ODN (Control for iODNs) Endotoxin-free (sterile)
​​​​​​​ IAX-200-203 ODN 2118 (Control for ODN 1585) Endotoxin-free (sterile)
​​​​​​​ IAX-200-204 ODN M383 (Control for ODN M362) Endotoxin-free (sterile)
​​​​​​​ IAX-200-205 ODN 2243 (Control for ODN 2216) Endotoxin-free (sterile)
​​​​​​​ ​​​​​​​IAX-200-206 ODN 2137 (Control for ODN 2006) Endotoxin-free (sterile)
​​​​​​​ IAX-200-208 CTRL2-ODN (Control for iODN and CpG-ODNs) Endotoxin-free (sterile)

​​​​​​​ IAX-400-002 Anti-TLR4 (Human) mAb (Blocking)
​​​​​​​ IAX-400-003 Anti-TLR4 (Human) mAb (2EII)
​​​​​​​ IAX-400-004-C100 Anti-TLR4 (human) mAb (28H7)

​​​​​​​ IAX-600-001 IAXO-101
​​​​​​​ IAX-600-002 IAXO-102
​​​​​​​ IAX-600-003 IAXO-103
​​​​​​​ IAX-600-004 IAXO-201 (Control for IAXO-102)
​​​​​​​ IAX-600-005 IAXO-202 (Control for IAXO-101 and IAXO-103)

​​​​​​​ IAX-700-001 Argania Spinosa Kernel Oil (natural) (pure)

​​​​​​​ IAX-700-100 Lipodisq Control (sterile)
​​​​​​​ ​​​​​​​IAX-700-101 Nano-Curcumin Lipodisq (sterile)
​​​​​​​ IAX-700-102 Melatonin Lipodisq (sterile)
​​​​​​​ IAX-700-103 Metformin Lipodisq (sterile)
​​​​​​​ IAX-700-104 Oxyresveratrol Lipodisq (sterile)
​​​​​​​ IAX-700-105 Resveratrol Lipodisq (sterile)
​​​​​​​ IAX-700-106 Umifenovir Lipodisq (sterile)
​​​​​​​ IAX-700-107 Dexamethasone Lipodisq
​​​​​​​ IAX-700-108 Ambroxol Lipodisq (sterile)
 
​​​​​​​ IAX-900-001 PBS Endotoxin-free (sterile)
​​​​​​​ IAX-900-002 ddWater Endotoxin-free (sterile)
​​​​​​​ IAX-900-003 Physiological Saline [NaCl 0.9%] Endotoxin-free (sterile)
​​​​​​​ IAX-900-004 PBS with EDTA Endotoxin-free (sterile)
​​​​​​​ IAX-900-005 TRIS with EDTA (TE Buffer) (100x)
​​​​​​​


Safety Data Sheets

​​​​​​​ IAX-100-001 Lipid A from S. minnesota R595 (Re) TLRpureTM Sterile Solution
​​​​​​​ IAX-100-002 MPLA from S. minnesota R595 (Re) TLRpureTM Sterile Solution
​​​​​​​ IAX-100-003 MPLA from E coli R515 (Re) TLRpureTM Sterile Solution
​​​​​​​ IAX-100-004 Lipid A from E. coli R515 (Re) TLRpureTM Sterlie Solution

​​​​​​​ IAX-100-006 LPS from E. coli O8:K27 (S-form) TLRpureTM Sterile Solution
​​​​​​​ IAX-100-007 LPS from E. coli R515 (Re) TLRpureTM Sterile Solution
​​​​​​​ IAX-100-008 LPS from S. minnesota R595 (Re) TLRpureTM Sterile Solution
​​​​​​​ IAX-100-009 LPS (Universal) from S. abortus equi (S-form) TLRpureTM Sterile Solution
​​​​​​​ IAX-100-009B LPS from S. abortus equi (S-form) Biotin TLRpureTM Sterile Solution
​​​​​​​ IAX-100-010 LPS from E. coli EH100 (Ra) TLRpureTM Sterile Solution
​​​​​​​ IAX-100-011 LPS from S. typhimurium (S-form) TLRpureTM Sterile Solution
​​​​​​​ IAX-100-012 LPS from E. coli O111:B4 (S-form) TLRpureTM Sterile Solution
​​​​​​​ IAX-100-013 LPS from E. coli O55:B5 (S-form) TLRpureTM Sterile Solution
​​​​​​​ IAX-100-014 LPS from E. coli J5 (Rc) TLRpureTM Sterile Solution
​​​​​​​ IAX-100-015 LPS from S. minnesota R345 (Rb) TLRpureTM Sterile Solution
​​​​​​​ IAX-100-016 LPS from S. minnesota R60 (Ra) TLRpureTM Sterile Solution
​​​​​​​ IAX-100-017 LPS from S. minnesota R5 (Rc) TLRpureTM Sterile Solution
​​​​​​​ IAX-100-018 LPS from S. minnesota R7 (Rd1) TLRpureTM Sterile Solution
​​​​​​​ IAX-100-019 LPS from S. enteritidis (S-form) TLRpureTM Sterile Solution
​​​​​​​ IAX-100-020 LPS from S. minnesota (S-form) TLRpureTM Sterile Solution
​​​​​​​ IAX-100-021 LPS from S. minnesota R3 (Rd2) TLRpureTM Sterile Solution

​​​​​​​ IAX-200-001 ODN 1668 (Type B) Endotoxin-free (sterile)
​​​​​​​ IAX-200-002 ODN 1826 (Type B) Endotoxin-free (sterile)
​​​​​​​ IAX-200-003 ODN 1585 (Type A) Endotoxin-free (sterile)
​​​​​​​ IAX-200-004 ODN M362 (Type C) Endotoxin-free (sterile)
​​​​​​​ IAX-200-005 ODN 2216 (Type A) Endotoxin-free (sterile)
​​​​​​​ IAX-200-006 ODN 2006 (Type B) Endotoxin-free (sterile)
​​​​​​​ IAX-200-007 ODN 2395 (Type C) Endotoxin-free (sterile)


​​​​​​​ IAX-200-050 iODN 2088 (Class I) Endotoxin-free (sterile)
​​​​​​​ IAX-200-051 iODN (ttaggg)4 (Class II) Endotoxin-free (sterile)
​​​​​​​ IAX-200-052 G-type iODN (Class I) Endotoxin-free (sterile)
​​​​​​​ IAX-200-053 Mini-iODN (Class I) Endotoxin-free (sterile)
​​​​​​​ IAX-200-054 Mega-iODN (Class I/ll) Endotoxin-free (sterile)
​​​​​​​ IAX-200-055 Duo-iODN (Class I) Endotoxin-free (sterile)
​​​​​​​ IAX-200-056 TLR7-iODN (inhibitory ODN) Endotoxin-free (sterile)

​​​​​​​ IAX-200-101 Trehalose 6,6’-dimycolate [Cord Factor] Endotoxin-free (sterile)

​​​​​​​ IAX-200-200 ODN 1720 (Control for ODN 1668) Endotoxin-free (sterile)
​​​​​​​ ​​​​​​​IAX-200-201 ODN 2138 (Control for ODN 1826) Endotoxin-free (sterile)
​​​​​​​ IAX-200-202 Neutral-ODN (Control for iODNs) Endotoxin-free (sterile)
​​​​​​​ IAX-200-203 ODN 2118 (Control for ODN 1585) Endotoxin-free (sterile)
​​​​​​​ IAX-200-204 ODN M383 (Control for ODN M362) Endotoxin-free (sterile)
​​​​​​​ IAX-200-205 ODN 2243 (Control for ODN 2216) Endotoxin-free (sterile)
​​​​​​​ ​​​​​​​IAX-200-206 ODN 2137 (Control for ODN 2006) Endotoxin-free (sterile)
​​​​​​​ IAX-200-208 CTRL2-ODN (Control for iODN and CpG-ODNs) Endotoxin-free (sterile)

​​​​​​​ IAX-600-001 IAXO-101
​​​​​​​ IAX-600-002 IAXO-102
​​​​​​​ IAX-600-003 IAXO-103

​​​​​​​ IAX-700-001 Argania Spinosa Kernel Oil (natural) (pure)

​​​​​​​ IAX-900-001 PBS Endotoxin-free (sterile)
​​​​​​​ IAX-900-002 ddWater Endotoxin-free (sterile)
​​​​​​​ IAX-900-003 Physiological Saline [NaCl 0.9%] Endotoxin-free (sterile)​​​​​​​



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