IAXO-101 (CD14/TLR4 Antagonist) (synthetic) Cat. No. #IAX-600-001

Name: IAXO-101 (CD14/TLR4 Antagonist) (synthetic) Cat. No. #IAX-600-001 - 1 mg, UK VAT
Brand: Innaxon
SKU: IAX-600-001-M001
Price: 222.00 GBP
Availability: InStock

The novel IAXO classes of glycolipid and benzylammonium lipids are synthetic TLR4/CD14 ligands with TLR4 modulating activities in vitro, and conferring protection against TLR4/CD14-mediated tissue damage and inflammation in vivo.

£185.00

Description Features Resources

Name	Methyl 6-deoxy-6-N-dimethyl-N-cyclopentylammonium-2, 3-di-O-tetradecyl- α-D-glucopyranoside iodide
Synonyms	FP1. Small molecule CD14/TLR4 ligand/modulator. Glycolipid. Lipid A analogue. Inhibitor of sterile inflammation.
Formula	C₄₂H₈₄INO₅
MW	810.02 g/mol (iodide salt)
CAS Number	1202388-64-4
Purity	≥98% according to TLC, NMR, MS analysis
Appearance	White solid

Solubility	Soluble in Methanol, DMSO and Ethanol 1:1 (vol:vol): >10mM
Handling	Reconstitution: For a 2mM stock solution, dissolve total vial content in 617µl (1mg size) in DMSO/Ethanol (1:1) (vol:vol).
Activity	Described to interfere with human, rat and mouse TLR4/CD14 signaling, other species not tested. Optimal working concentration depends upon the type, purity and concentration and of TLR4 ligand, carrier protein such as LPS-binding protein (LBP), soluble and membrane-bound CD14, the presence of TLR4 co-receptors (e.g. CD36) as well on type and time of read-out (e.g. cytokine measurement in cell culture supernatant) or the biological outcome of in vivo experiments and therefore needs to be determined for each application. Recommended starting concentration: in vitro: 5µM, in vivo (rodent): 3mg/kg.

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