Potent and TLR4-exclusive ligands, devoid of other TLR stimulating contaminants in a stable, sterile aqueous solution for maximal reproducibility of experiments, especially for pre-clinical use.
Lipid-nanodisc formulation with solubilised hydrophobic actives in water (sterile) Ready-to-Use
Polymeric SMA-Lipodisq Lipid nano-particles (SMA-LNP) are useful as drug delivery systems comprising a discoidal phospholipid bilayer membrane stabilised by a chaperone molecule annulus (11-40nm).
The resulting encapsulated actives are rendered water-soluble and specialised for intra-cellular penetration/delivery via endosomal uptake mechanisms, which allow for improved PK/PD of the API.