Specialist manufacturer of LPS and endotoxin-free reagents

TLR4 Specific Agonists Lipopolysaccharides (LPS), Lipid A, MPLA

Potent and TLR4-exclusive ligands, devoid of other TLR stimulating contaminants in a stable, sterile aqueous solution for maximal reproducibility of experiments, especially for pre-clinical use.
TLR4/CD14 Inhibitors TLR4 MAbs and IAXO (synthetic)

IAXO/FP small molecules as synthetic lipid A analogues and high potency human Toll-like Receptor (TLR) 4 blocking monoclonal antibodies.
TLR9 and TLR7 Ligands Endotoxin-free (sterile)
Immunoceuticals (sterile)
- iODNs (inhibitory ODNs)
- Mincle Agonist: TDM [Cord Factor]
Endotoxin-free Buffers & Solutions (sterile)

Endotoxin-free Buffers & Solutions (sterile) are important for reproducible and specific endotoxin and endotoxin-free preparations.
Polymeric SMA-Lipodisq Lipid nano-particles (SMA-LNP)
Lipid-nanodisc formulation with solubilised hydrophobic actives in water (sterile) Ready-to-Use
- Polymeric SMA-Lipodisq Lipid nano-particles (SMA-LNP) are useful as drug delivery systems comprising a discoidal phospholipid bilayer membrane stabilised by a chaperone molecule annulus (11-40nm).
- The resulting encapsulated actives are rendered water-soluble and specialised for intra-cellular penetration/delivery via endosomal uptake mechanisms, which allow for improved PK/PD of the API.
Resources
- Flyers
- Literature
  
  Selected Innaxon literature citations
- Product Data Sheets
- Safety Data Sheets
About Innaxon Biosciences

Featured products

Retinoic Acid powered by LipodisqTM Sterile Solution Cat. No. #IAX-700-109

£165.00

• Vitamin A is a fat-soluble micronutrient necessary for the growth of healthy skin and hair. However, both too little and too much vitamin A has deleterious effects. All-transretinoic acid (ATRA) and retinal are the main active metabolites of vitamin A. Retinoic acid dose-dependently regulates hair follicle stem cells, influencing the functioning of the hair cycle, wound healing, and melanocyte stem cells. Retinoic acid also influences melanocyte differentiation and proliferation in a dose-dependent and temporal manner. Levels of retinoids decline when exposed to ultraviolet irradiation in the skin.

• All-trans-retinoic acid (ATRA) is effective for preventing cancer and treating skin diseases and acute promyelocytic leukaemia (APL). These pharmacological effects of ATRA are mainly mediated by retinoid X receptors (RXRs) and retinoic acid receptors (RARs). These included two families of receptors, the RAR isotypes (a,b, and g) along with three RXR isotypes (a,b, and g), which bind as RXR/RAR heterodimers to cis-acting response elements of RA target genes to generate a high degree of complexity. • Retinoic acid is used in the treatment of psoriasis, ichthyosis, follicular keratosis, acne, lichen planus, verrucous epidermal nevus, impetigo, vitiligo, lichen psoriasis, the face of pityriasis alba.

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DMPC (1,2-Dimyristoyl-sn-glycero-3-phosphocholine) (14:0 PC) Cat. No. #IAX-700-400

From: £42.00

• A nanoparticle (11-40nm) drug delivery system comprising a discoidal phospholipid bilayer membrane stabilised by a chaperone molecular annulus.

• Lipodisq^TM polymers are available as 4 defined structures (1:1, 2:1, 3:1 and 4:1 Styrene to Maleic Acid (SMA) rations) each individually operational within a selected pH range for optimal working conditions.

• Components are batch-tested for Lipodisq^TM formation using buffer systems available, which are tested for nano-formulated drug analysis by Dynamic Light Scattering (DLS). These buffer solutions are endotoxin-tested and sterile.

• Lipodisq^TM formation is highly efficient and nanodiscs show a good safety profile and are suitable for in vitro and in vivo (in experimental animals) investigations.

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Lipodisq™ Styrene:Maleic Acid Copolymer 1:1 [SMA-100] Cat. No. #IAX-700-201

£140.00

• A nanoparticle (11-40nm) drug delivery system comprising a discoidal phospholipid bilayer membrane stabilised by a chaperone molecular annulus.

• LipodisqTM polymers are available as 4 defined structures (1:1, 2:1, 3:1 and 4:1 Styrene to Maleic Acid (SMA) rations) each individually operational within a selected pH range for optimal working conditions.

• Components are batch-tested for LipodisqTM formation using buffer systems available, which are tested for nano-formulated drug analysis by Dynamic Light Scattering (DLS). These buffer solutions are endotoxin-tested and sterile.

• LipodisqTM formation is highly efficient and nanodiscs show a good safety profile and are suitable for in vitro and in vivo (in experimental animals) investigations.

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Lipodisq™ Styrene:Maleic Acid Copolymer 2:1 [SMA-200] Cat. No. #IAX-700-202

£140.00

• A nanoparticle (11-40nm) drug delivery system comprising a discoidal phospholipid bilayer membrane stabilised by a chaperone molecular annulus.

• LipodisqTM polymers are available as 4 defined structures (1:1, 2:1, 3:1 and 4:1 Styrene to Maleic Acid (SMA) rations) each individually operational within a selected pH range for optimal working conditions. • Components are batch-tested for LipodisqTM formation using buffer systems available, which are tested for nano-formulated drug analysis by Dynamic Light Scattering (DLS). These buffer solutions are endotoxin-tested and sterile.

• LipodisqTM formation is highly efficient and nanodiscs show a good safety profile and are suitable for in vitro and in vivo (in expermental animals) investigations.

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Lipodisq™ Styrene:Maleic Acid Copolymer 3:1 [SMA-300] Cat. No. #IAX-700-203

£140.00

• A nanoparticle (11-40nm) drug delivery system comprising a discoidal phospholipid bilayer membrane stabilised by a chaperone molecular annulus.

• LipodisqTM polymers are available as 4 defined structures (1:1, 2:1, 3:1 and 4:1 Styrene to Maleic Acid (SMA) rations) each individually operational within a selected pH range for optimal working conditions. • Components are batch-tested for LipodisqTM formation using buffer systems available, which are tested for nano-formulated drug analysis by Dynamic Light Scattering (DLS). These buffer solutions are endotoxin-tested and sterile.

• LipodisqTM formation is highly efficient and nanodiscs show a good safety profile and are suitable for in vitro and in vivo (in expermental animals) investigations.

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Lipodisq™ Styrene:Maleic Acid Copolymer 4:1 [SMA-400] Cat. No. #IAX-700-204

£140.00

• A nanoparticle (11-40nm) drug delivery system comprising a discoidal phospholipid bilayer membrane stabilised by a chaperone molecular annulus.

• LipodisqTM polymers are available as 4 defined structures (1:1, 2:1, 3:1 and 4:1 Styrene to Maleic Acid (SMA) rations) each individually operational within a selected pH range for optimal working conditions. • Components are batch-tested for LipodisqTM formation using buffer systems available, which are tested for nano-formulated drug analysis by Dynamic Light Scattering (DLS). These buffer solutions are endotoxin-tested and sterile.

• LipodisqTM formation is highly efficient and nanodiscs show a good safety profile and are suitable for in vitro and in vivo (in expermental animals) investigations.

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PBS Endotoxin-free (sterile) [For Nano-formulated Drug Analysis] Cat. No. #IAX-900-001DC

£58.33

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ddWater Endotoxin-free (sterile) [For Nano-formulated Drug Analysis] Cat. No. #IAX-900-002DC

£58.33

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Physiological Saline Endotoxin-free (sterile) [For Nano-formulated Drugs] Cat. No. #IAX-900-003DC

£47.00

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DNA Loading Buffer with TRIS and EDTA (6x) (Blue) Cat. No. #IAX-900-008

£47.00

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HEPES Buffer (50mM) with NaCl [Sodium Chloride] (150mM Endotoxin-free (sterile) Cat. No #IAX-900-009

£74.46

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NaCl [Sodium Chloride] (1.5M) Endotoxin-free (sterile) Cat. No. #IAX-900-010

£74.46

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TRIS Buffer (1.5M) Endotoxin-free (sterile) Endotoxin-free (sterile) Cat. No. #IAX-900-011

£74.46

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TRIS Buffer (30mM) with NaCl [Sodium Chloride] (150mM) Endotoxin-free (sterile) Cat. No #IAX-900-012

£74.46

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Lipodisq® Formulation Services

£0.00

Please contact Innaxon for more information: info@innaxon.com
PBS with Magnesium and Calcium Endotoxin-free (sterile) Cat. No. #IAX-900-013

£74.46

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ddWater with O.9% Benzyl Alcohol Cat. No. #IAX-900-014

From: £58.00

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